The pattern of pro- and anti-inflammatory cytokine secretion in patients with secondary edematous breast cancer

Secondary edematous breast cancer (SEBC), T4b, has a poor prognosis. The aim of this study is to examine the balance in serum levels pro-inflammatory (TNFά, IL-8) and anti-inflammatory (IL-4) cytokines patients with SEBC before special treatment. Materials methods. A total 87 (BC) were examined treatment: 42 T4bN0-3M0 stage 45 BC T3-4N1-3M0 without edema. control group consisted 15 fibroadenomas. (IL-4, IL-8, TNFά) was determined using enzyme-linked immunosorbent assay. Results. In as compared cancer, cytokine (IL-8, significantly increased level slightly 22 %. edema, an imbalance noted favor cytokines, but it more pronounced (31.6 versus 12.4 5.6 3.2, respectively). Conclusions. majority patients, there profile TNFά). elevated both pro- treatment are highest risk tumor progression metastasis. Inhibition IL-8 effects or related CXC chemokines, TNFά, others may have important consequences for systemic SEBC.